The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2021
Filed:
Mar. 23, 2018
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Phoenixbio Co., Ltd., Higashihiroshima, JP;
Michinori Kohara, Tokyo, JP;
Koichi Jishage, Gotemba, JP;
Yosuke Kawase, Gotemba, JP;
Chise Mukaidani, Higashihiroshima, JP;
Hiroki Oshita, Higashihiroshima, JP;
Satoko Hamamura, Higashihiroshima, JP;
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, Tokyo, JP;
CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;
PHOENIXBIO CO., LTD., Higashihiroshima, JP;
Abstract
The present invention provides a mouse with liver damage, having a high degree of damage against the mouse's original hepatocytes while having a uPA gene in a heterozygous form, and a method for efficiently preparing the mouse. Specifically, the method for preparing a mouse with liver damage having the uPA gene in a heterozygous form comprises the following steps of: