Location History:
- Shizuoka, JP (2011)
- Gotemba, JP (2018 - 2021)
Company Filing History:
3 out of 950 
2 out of 55 
2 out of 7 
Years Active: 2011-2021
Title: Yosuke Kawase: Innovator in Transgenic Technology
Introduction: Yosuke Kawase is a prominent inventor based in Gotemba, Japan, known for his significant contributions to the field of genetic engineering. With a total of three patents to his name, Kawase has been instrumental in advancing research through innovative inventions that provide valuable insights into liver damage and its implications.
Latest Patents: Among his latest inventions, Kawase's notable patent involves the "Urokinase-type plasminogen activator transgenic mouse." This patent describes a mouse model with liver damage characterized by a high degree of injury to its native hepatocytes while possessing a heterozygous uPA gene. His invention includes a detailed method for efficiently generating this transgenic mouse, which involves several key steps: transforming mouse embryonic stem cells with a DNA fragment containing a liver-specific promoter/enhancer and cDNA for urokinase-type plasminogen activator; injecting these transformed cells into a host embryo; transplanting the embryo into a surrogate mother mouse; and ultimately crossing the resulting chimeric mice to achieve a transgenic mouse modeled for research in hepatic conditions.
Career Highlights: Kawase's career is marked by his association with esteemed organizations, including Chugai Pharmaceutical Co., Ltd. and the Tokyo Metropolitan Institute of Medical Science. His work in these institutions has allowed him to develop innovative techniques and methods that significantly impact scientific understanding of liver disease and treatment.
Collaborations: Throughout his career, Kawase has collaborated with several notable coworkers, including Michinori Kohara and Koichi Jishage. These partnerships have facilitated the exchange of ideas and fostered a collaborative environment that has been essential for the realization of his inventive projects.
Conclusion: Yosuke Kawase stands out as a key figure in the realm of genetic research, particularly through his work on transgenic models that aid in the study of liver damage. His patents serve as a testament to his inventive spirit and dedication to advancing medical science, making significant contributions that could lead to new treatments and further understanding of hepatic conditions.