Keith R Olson

Title: Innovator Keith R Olson: Pioneering Advances in Nuclear Hormone Receptor Research

Introduction

Keith R Olson, an accomplished inventor based in Pleasanton, CA, has made significant contributions to the field of nuclear hormone receptor research. With a portfolio of three patents, Olson's innovations focus on methods and genetic constructs for detecting the binding interactions of nuclear hormone receptors. His work enhances our understanding of cellular processes and has implications for various applications in biomedical research.

Latest Patents

Olson's latest patents include cutting-edge methods for detecting the binding of nuclear hormone receptors to coactivators and corepressors. This innovative approach utilizes enzyme fragment complementation with fragments of β-galactosidase to serve as the detection system. The described methods involve transforming cells to express a large fragment of β-galactosidase, which is fused to a member of the transcription initiation complex localized in the nucleus. Additionally, cells express a small fragment of β-galactosidase fused to the nuclear hormone receptor to facilitate binding upon stimulation with a ligand. Moreover, Olson has developed truncated fragments of the small fragment of β-galactosidase, which maintain low affinity for the large fragment, allowing for robust signaling when fusion proteins from complex binding occur.

Career Highlights

During his career at DiscoverX Corporation, Olson has been pivotal in advancing molecular biology techniques. His inventive work surrounding nuclear hormone receptors and their interactions has led to innovations that can significantly impact drug discovery and development. His contributions not only enhance scientific knowledge but also establish practical applications for therapeutic interventions.

Collaborations

Olson works alongside esteemed colleagues such as Thomas S Wehrman and Chin Yee Loh, fostering a collaborative environment that promotes innovation and progress within their research initiatives. Their combined expertise and teamwork enable the exploration of complex biological questions and the development of novel methodologies.

Conclusion

Keith R Olson’s inventive journey illustrates the importance of innovation in scientific research. With his latest patents focusing on nuclear hormone receptor binding, Olson continues to push the boundaries of knowledge and technology in molecular biology. His collaborations at DiscoverX Corporation promise to lead to further advancements that could revolutionize our approach to understanding and manipulating cellular processes.