The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Aug. 06, 2009
Wei Feng, Fremont, CA (US);
William Raab, San Francisco, CA (US);
Philip Achacoso, Union City, CA (US);
Thomas Wehrman, East Palo Alto, CA (US);
Keith R. Olson, Pleasanton, CA (US);
Wei Feng, Fremont, CA (US);
William Raab, San Francisco, CA (US);
Philip Achacoso, Union City, CA (US);
Thomas Wehrman, East Palo Alto, CA (US);
Keith R. Olson, Pleasanton, CA (US);
DiscoveRx Corporation, Fremont, CA (US);
Abstract
Methods for detecting phosphorylation of receptor tyrosine kinases ('RTKs') upon activation are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large fragment of β-galactosidase, where the 2 fragments weakly complex to form an active enzyme, and optionally a construct for a cytosolic RTK phosphorylating kinase, when the RTK does not autophosphoryate. To detect phosphorylation a β-galactosidase substrate is added to the cells, whereby product formation indicates the occurrence of phosphorylation.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile