Keith Earl Robison

Title: **The Innovations of Keith Earl Robison: A Pioneer in Biological Modulation**

Introduction

Keith Earl Robison, an accomplished inventor based in Andover, MA, has made significant contributions to the field of biological sciences through his innovations. With a portfolio comprising five patents, Robison's work focuses on the modulation of biological processes, showcasing his expertise in this dynamic field.

Latest Patents

Among his latest patents, one notable invention is centered around "Compounds that participate in cooperative binding and uses thereof." This invention highlights the development of macrocyclic compounds that can effectively interact with presenter proteins—specifically those from the FKBP and cyclophilin families. These compounds play a critical role in the formation of binary complexes, selectively modulating the activity of target proteins, such as CEP250. The formation of a tripartite complex is fundamental to his research, relying on intricate protein-compound and protein-protein interactions.

Another significant patent involves "Compositions and methods for the production of compounds." This disclosure addresses the encoding of nucleic acids for a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors. The patent encompasses methodologies for generating valuable compounds, including polyketides and β-lactam compounds, thus contributing to advancements in biotechnology.

Career Highlights

Robison has worked with several prestigious companies, including Revolution Medicines, Inc. and Ginkgo Bioworks, Inc. These roles have allowed him to further his research interests and apply his innovative ideas in a corporate setting, enhancing the impact of his inventions.

Collaborations

Throughout his career, Robison has collaborated with esteemed colleagues such as Gregory Lawrence Verdine and Brian Roger Bowman. These partnerships underline his commitment to advancing research in biological modulation and demonstrate the collaborative nature of scientific innovation.

Conclusion

Keith Earl Robison's contributions to the field of biological sciences are evident through his innovative patents and collaborative efforts. His work continues to pave the way for advancements in biological modulation, reflecting the potential for significant breakthroughs in therapeutic applications and biotechnology.