Revolution Medicines, Inc.

Ginkgo Bioworks, Inc.

Warp Drive Bio, Inc.

Keith Earl Robison

Gregory Lawrence Verdine

Jay Paul Morgenstern

Brian Roger Bowman

Mathew Edward Sowa

Dylan Talbot Stiles

Sharon Ann Townson

Uddhav Kumar Shigdel

Joshua Alan Van Dyke Blodgett

Daniel C Gray

Lucy Foulston

Joshua A V Blodgett

Joshua AV Blodgett

The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Compounds that participate in cooperative binding and uses thereof

The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or &#x3b2;-lactam compounds) with such nucleic acids, vectors, and/or host cells.

Compositions and methods for the production of compounds

The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for ex ample through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Growing community of inventors

Andover, MA, United States of America

Keith Earl Robison