The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2020
Filed:
Jan. 08, 2016
Revolution Medicines, Inc., Redwood City, CA (US);
Gregory Lawrence Verdine, Boston, MA (US);
Brian Roger Bowman, New Rochelle, NY (US);
Mathew Edward Sowa, Watertown, MA (US);
Joshua Alan Van Dyke Blodgett, Webster Groves, MO (US);
Keith Earl Robison, Andover, MA (US);
Dylan Talbot Stiles, Cambridge, MA (US);
Jay Paul Morgenstern, Boston, MA (US);
Sharon Ann Townson, Cambridge, MA (US);
Uddhav Kumar Shigdel, East Meadow, NY (US);
Revolution Medicines, Inc., Redwood City, CA (US);
Abstract
The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.