Location History:
- Carey, NC (US) (1999)
- Cary, NC (US) (1998 - 2012)
Company Filing History:
18 out of 91 
2 out of 832,891 Years Active: 1998-2012
Title: Innovations in Ocular Health: The Patents of Karla M Jacobus
Introduction
Karla M Jacobus, based in Cary, NC, is a prominent inventor with an impressive portfolio of 20 patents. Her groundbreaking work primarily focuses on methods for increasing tear production and treating dry eye disease. Jacobus's innovations are set to make significant contributions to the field of ocular health, providing much-needed solutions for patients suffering from related conditions.
Latest Patents
Among her latest patents is a method of increasing tear production with purinergic receptor agonists. This patent outlines a novel technique for stimulating tear secretion through the administration of purinergic receptor agonists such as uridine 5'-triphosphate (UTP), adenine 5'-triphosphate (ATP), and their analogs. The methods of administration include topical applications via a gel, liquid, or cream, and systemic methods such as nasal sprays or oral forms. Another notable patent addresses the method of treating dry eye disease using the same class of agonists, emphasizing effective tear fluid secretion and enhancing drainage in the lacrimal system.
Career Highlights
Jacobus has made a substantial impact in the pharmaceutical field through her association with Inspire Pharmaceuticals, Inc., where she contributed to significant innovations in ophthalmology. Her dedication and expertise have led to the successful patenting of essential methods that address common ocular disorders.
Collaborations
Throughout her career, Jacobus has collaborated with esteemed colleagues, including Janet L Rideout and William Pendergast. These partnerships have fostered a collaborative environment that enhances the development of innovative treatments in ocular health.
Conclusion
Karla M Jacobus stands out as a leading inventor in the realm of ocular health, with her substantial patent portfolio demonstrating her innovative approaches to treating conditions such as dry eye disease. Her work not only showcases her commitment to improving patient outcomes but also highlights the importance of collaboration and research in driving medical advancements.