Jonathan Mark Gleadle

Title: The Innovations of Jonathan Mark Gleadle

Introduction

Jonathan Mark Gleadle is a notable inventor based in Oxford, GB. He has made significant contributions to the field of biochemistry, particularly in the area of hydroxylation processes. His work has implications for understanding cellular responses to oxygen levels, which is crucial in various biological and medical contexts.

Latest Patents

Gleadle holds a patent titled "Assays for modulators of asparaginyl hydroxylase." This patent describes a method for identifying agents that modulate the hydroxylation of hypoxia-inducible factor (HIF). The method involves contacting a HIF asparagine hydroxylase with a test substance in the presence of a substrate under specific conditions. The substrate is typically a HIF polypeptide, such as HIF-1α, or a fragment thereof. The patent outlines how to determine the hydroxylation of the substrate, which is essential for understanding the regulation of HIF activity.

Career Highlights

Gleadle is associated with Isis Innovation Limited, where he has been able to apply his expertise in biochemistry and patent development. His work has contributed to advancements in the understanding of HIF and its role in cellular responses to hypoxia.

Collaborations

Throughout his career, Gleadle has collaborated with esteemed colleagues, including Christopher William Pugh and Peter John Ratcliffe. These collaborations have further enriched his research and innovation efforts.

Conclusion

Jonathan Mark Gleadle's contributions to the field of biochemistry, particularly through his patent on HIF modulation, highlight his role as an influential inventor. His work continues to impact the understanding of cellular mechanisms in response to oxygen levels.