Company Filing History:
14 out of 258 
2 out of 3 
2 out of 12 Years Active: 2017-2024
Title: The Innovations and Contributions of Jonathan Lorne Bramson
Introduction
Jonathan Lorne Bramson, based in Oakville, Canada, is a distinguished inventor known for his significant contributions to the field of immunology. With a remarkable portfolio of 16 patents, his work focuses on enhancing T cell functionality through innovative molecular designs. His inventions have the potential to revolutionize therapeutic strategies in cancer treatment and immune responses.
Latest Patents
Bramson's recent patents showcase his expertise in developing trifunctional molecules aimed at optimizing T cell responses. One of his latest innovations is a T cell-antigen coupler that features various construct optimizations. This trifunctional molecule comprises a target-specific ligand, a ligand that binds to a protein associated with the T cell receptor (TCR) complex, and a T cell receptor signaling domain polypeptide. Notably, the invention includes variants that enhance surface expression, transduction efficiency, and overall effector functionality, utilizing different ligands that bind CD3 epsilon, signaling domains, and flexible linkers between domains.
Another significant patent from Bramson is his T cell-antigen coupler with a Y182T mutation, which provides a novel trifunctional molecule comprising similar components as his previous invention. This specific ligand, which binds a protein associated with the TCR complex, is UCHT1 modified with a Y182T mutation. The engineered T cells with this novel receptor achieve antigen-specific activation of various T cell functions, including cytokine production, degranulation, and cytolysis.
Career Highlights
Throughout his career, Jonathan Bramson has worked with esteemed institutions such as McMaster University and Triumvira Immunologics USA, Inc. His research and innovations in immunotherapy have positioned him as a key figure in advancing T cell engineering, thereby contributing to potential breakthroughs in cancer therapy.
Collaborations
Bramson has collaborated with talented individuals such as Christopher W. Helsen and Kenneth Anthony Mwawasi. These partnerships have played a crucial role in enhancing the scope of his research and fostering the development of cutting-edge therapeutic approaches in immunology.
Conclusion
In conclusion, Jonathan Lorne Bramson is an exemplary inventor whose patents and innovations in the field of immunology reflect his commitment to advancing therapeutic possibilities for patients. With a proven track record and collaborations with prominent researchers, his work continues to influence the landscape of cancer treatment and immune modulation through T cell optimization.