The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2021
Filed:
May. 06, 2020
Applicant:
Mcmaster University, Hamilton, CA;
Inventors:
Jonathan Bramson, Oakville, CA;
Christopher W. Helsen, Oakville, CA;
Galina Denisova, Hamilton, CA;
Rajanish Giri, Telliarganj Allahabad, IN;
Kenneth Anthony Mwawasi, Hamilton, CA;
Assignee:
McMaster University, Hamilton, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/73 (2006.01); C07K 16/28 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70514 (2013.01); A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C07K 16/2809 (2013.01); C07K 16/32 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2318/20 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01);
Abstract
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.