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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11970545 B1

PDFFull Text
Date of Patent:
Apr. 30, 2024

Filed:

Mar. 22, 2023

T cell-antigen coupler with y182t mutation and methods of uses thereof

Applicant:

Mcmaster University, Hamilton, CA;

Inventors:

Christopher W. Helsen, Oakville, CA;

Jonathan Bramson, Oakville, CA;

Anna Dvorkin-Gheva, Burlington, CA;

Galina F. Denisova, Hamilton, CA;

Ksenia Bezverbnaya, Hamilton, CA;

Kenneth Anthony Mwawasi, Vancouver, CA;

Assignee:

McMaster University, Hamilton, CA;

Attorney:

Goodwin Procter LLP

Primary Examiner:

Amy E Juedes

Assistant Examiner:

Brian undefined Hartnett

Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01); A61K 39/385 (2006.01); A61P 35/00 (2006.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/3061 (2013.01); A61K 9/0019 (2013.01); A61K 38/00 (2013.01); A61K 39/385 (2013.01); A61P 35/00 (2018.01); C07K 14/525 (2013.01); C07K 14/7051 (2013.01); C07K 14/70514 (2013.01); C07K 14/70517 (2013.01); C07K 16/2809 (2013.01);
Abstract

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Find Patent Forward Citations

Helsen, Christopher. (2024). T cell-antigen coupler with y182t mutation and methods of uses thereof (U.S. Patent No. 11970545). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11970545

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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