Jon Richard Heal

Title: Jon Richard Heal: Innovator in Biochemical Synthesis

Introduction

Jon Richard Heal is a notable inventor based in Reinach, Switzerland. He has made significant contributions to the field of biochemical synthesis, particularly in the development of norcoclaurine synthases and cytochrome P450 enzymes. With a total of 2 patents, his work has implications for the production of important chemical compounds.

Latest Patents

One of Jon's latest patents focuses on norcoclaurine synthases with increased activity. This invention relates to specific mutations in substrate binding sites that enhance the condensation of 4-HPAA and dopamine to (S)-norcoclaurine. The identified mutations correspond to positions 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174, and/or 178, which are crucial for increasing the activity of these synthases. Another significant patent involves the demethylation of reticuline and its derivatives using fungal cytochrome P450 enzymes. This invention provides methods for producing N-demethylated and/or O-demethylated reticuline, which are valuable for accessing naturally unavailable starting materials for opioids.

Career Highlights

Jon Richard Heal is currently associated with River Stone Biotech LLC, where he continues to innovate in the field of biochemical research. His work has garnered attention for its potential applications in pharmaceuticals and natural product synthesis.

Collaborations

Jon has collaborated with notable colleagues such as Markus Schwab and Philipp Friedrich Berninger. Their combined expertise contributes to the advancement of research in their respective fields.

Conclusion

Jon Richard Heal's contributions to biochemical synthesis through his innovative patents highlight his role as a leading inventor in the industry. His work not only advances scientific knowledge but also has practical applications in the production of essential chemical compounds.