The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Jun. 18, 2018
River Stone Biotech Llc, Cambridge, MA (US);
Markus Schwab, Reinach, CH;
Sumire Honda Malca, Reinach, CH;
Philipp Friedrich Berninger, Reinach, CH;
Jon Richard Heal, Reinach, CH;
Joseph Michael Sheridan, Reinach, CH;
Laura Tatjer Recorda, Copenhagen, DK;
Rubini Maya Kannangara, Copenhagen, DK;
Esben Halkjaer Hansen, Copenhagen, DK;
Angela Manuela Ribeiro de Carvalho, Copenhagen, DK;
RIVER STONE BIOTECH, LLC, Cambridge, MA (US);
Abstract
The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.