Location History:
- Chicago, IL (US) (1990 - 2007)
- Thousand Oaks, CA (US) (2006 - 2007)
Company Filing History:
37 out of 1,323 
3 out of 200 
1 out of 3,288 Years Active: 1990-2007
Areas of Expertise:
Title: Innovations and Contributions of John S Ng in Biotechnology
Introduction
John S Ng, based in Chicago, IL, is a notable inventor with a remarkable portfolio of 42 patents. His contributions primarily lie in the field of biotechnology, particularly focusing on enzymes and their applications in bioconversion processes. Ng's inventive work continues to pave the way for advancements in medical and agricultural technologies.
Latest Patents
One of Ng's latest patents describes a novel cytochrome P450-like enzyme (11 alpha hydroxylase) and an oxidoreductase isolated from a cDNA library generated from the mRNA of spores. This innovative enzyme catalyzes the conversion of the steroid substrate 4-androstene-3,17-dione (AD) to 11 alpha-hydroxy-AD, a process confirmed through HPLC analysis. Additionally, this invention encompasses nucleic acid molecules associated with the cDNAs, which can be used to generate polypeptides and their fragments. Another significant aspect of this patent involves the generation of antibodies that recognize these proteins, allowing for the detection of both native and recombinant forms within various host cells. Furthermore, methods for expressing the 11 alpha hydroxylase gene in heterologous host cells are included, aimed at facilitating the bioconversion of steroid substrates.
Another recent patent focuses on a synthesis method for intermediates useful in the large-scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. This method utilizes a diastereoselective epoxide formation from a chiral alpha amino aldehyde, showcasing Ng’s innovative approach to addressing critical health challenges.
Career Highlights
During his career, John S Ng has worked with reputable organizations, including G.D. Searle & Company and Pharmacia Corporation. His roles in these companies have allowed him to apply his expertise and drive innovation in the field of biotechnological research and development.
Collaborations
Ng has collaborated with accomplished professionals such as Chin Liu and Ping T Wang, enhancing the scope and impact of his inventive projects. These partnerships reflect a collaborative spirit in the scientific community, which is essential for advancing biotechnological innovations.
Conclusion
John S Ng's extensive patent portfolio and innovative work demonstrate his vital role in the biotechnology sector. His inventions not only contribute to scientific knowledge but also have practical applications that can significantly benefit society. The innovations brought forth by Ng position him as a prominent figure in the realm of biotechnology and patent development.