John S Chiu

Title: Innovations and Contributions of John S Chiu

Introduction

John S Chiu is a notable inventor based in Parsippany, NJ, with a remarkable portfolio of 11 patents. His work primarily focuses on the synthesis of chemical compounds that have significant applications in pharmaceuticals.

Latest Patents

One of his latest patents is titled "Process for the synthesis of azetidinones." This patent describes a method for preparing azetidinones, which are useful as intermediates in the synthesis of penems and as hypocholesterolemic agents. The process involves reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent. The cyclizing agent can be selected from various groups, including alkali metal carboxylates and quaternary ammonium compounds.

Another significant patent is for the "Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof." This application provides a process for introducing nitro-group functionality into a compound that also contains a site of unsaturation and/or oxygen functionality. The method involves the direct oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex.

Career Highlights

Throughout his career, John S Chiu has worked with prominent companies such as Schering Corporation and Merck Sharp & Dohme Corporation. His contributions to these organizations have been instrumental in advancing pharmaceutical research and development.

Collaborations

John has collaborated with notable coworkers, including Tiruvettipuram K Thiruvengadam and Chou-Hong Tann. These collaborations have further enriched his work and expanded the impact of his inventions.

Conclusion

John S Chiu's innovative contributions to the field of chemistry and pharmaceuticals are evident through his numerous patents and collaborations. His work continues to influence the development of important chemical compounds.