The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 1995
Filed:
Oct. 15, 1993
Applicant:
Inventors:
Chou-Hong Tann, Berkeley Heights, NJ (US);
Tiruvettipuram K Thiruvengadam, Edison, NJ (US);
John S Chiu, Parsippany, NJ (US);
Cesar Colon, Rahway, NJ (US);
Michael D Green, Paterson, NJ (US);
Assignee:
Schering Corporation, Kenilworth, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ;
U.S. Cl.
CPC ...
536 136 ; 536 185 ; 536 186 ;
Abstract
An improved process for converting gentamicin B to isepamicin comprising forming 3,6'-di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylating agent, 2-formylmercaptobenzothiazole, and intermediate compounds are also disclosed.