Company Filing History:
Years Active: 1992-1997
Title: John Lister-James: Innovator in Antibody Labeling Technologies
Introduction
John Lister-James is a notable inventor based in Glenmoore, PA (US). He has made significant contributions to the field of biochemistry, particularly in the area of antibody labeling. With a total of 3 patents to his name, Lister-James has developed innovative methods that enhance the efficacy of antibody applications in medical diagnostics.
Latest Patents
One of his latest patents is titled "One vial method for labeling antibodies with Technetium-99m." This invention discloses a method for labeling a sulfhydryl-containing antibody or antibody fragment with technetium-99m. The process involves contacting an antibody mixture, which includes a reducing agent, with technetium-99m in an oxidized state. In a preferred embodiment, the mixture also contains a water-soluble ligand. Additionally, he has developed a one vial kit for this labeling process.
Another significant patent is focused on "Cross-linking protein compositions having two or more identical binding." This invention provides cross-linked protein compositions that consist of multiple units of a target-specific protein. These units are joined by binding sulfhydryl groups to a sulfhydryl-selective cross-linking agent. The resulting compositions enhance binding affinity and stability under reduction conditions.
Career Highlights
John Lister-James is currently associated with Centocor, Inc., where he continues to innovate in the field of biochemistry. His work has been instrumental in advancing techniques that improve the reliability and effectiveness of antibody-based diagnostics.
Collaborations
Throughout his career, Lister-James has collaborated with esteemed colleagues, including Richard T Dean and Raymond H Boutin. These partnerships have contributed to the development of groundbreaking technologies in the field.
Conclusion
John Lister-James is a prominent inventor whose work in antibody labeling technologies has made a significant impact in the field of biochemistry. His innovative patents and collaborations reflect his commitment to advancing medical diagnostics.
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