The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 1993
Filed:
Apr. 09, 1990
Applicant:
Inventors:
Richard T Dean, Dowingtown, PA (US);
John Lister-James, Glenmoore, PA (US);
Raymond H Boutin, Wilmington, DE (US);
Assignee:
Centocor, Inc., Malvern, PA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; A61K / ;
U.S. Cl.
CPC ...
5303911 ; 5303873 ; 5303913 ; 5303915 ; 5303917 ; 5303919 ; 530403 ; 530408 ; 530409 ; 424 858 ; 424 8591 ; 435972 ; 436512 ; 436547 ; 436819 ;
Abstract
The present invention provides cross-linked protein compositions consisting of two or more units of a target-specific protein joined by binding sulfhydryl groups on the target-specific protein units to a sulfhydryl-selective cross-linking agent and a method of making the compositions. These cross-linked protein compositions combine an increase in binding affinity due to the presence of multiple identical binding sites and stability to reduction conditions.