Location History:
- Brookline, MA (US) (1996 - 1998)
- Newton, MA (US) (1998 - 2005)
- Weston, MA (US) (2017)
Company Filing History:
9 out of 2,971 
1 out of 1,039 
1 out of 449 
Years Active: 1996-2017
Title: John G. Flanagan: Innovator in Neuronal Growth and Signaling
Introduction
John G. Flanagan is a prominent inventor based in Newton, MA (US), known for his significant contributions to the field of neuronal growth and signaling. With a total of 9 patents, Flanagan has made remarkable strides in understanding and promoting neuronal outgrowth, which has implications for treating neuronal injuries and various medical conditions.
Latest Patents
Flanagan's latest patents include innovative methods for promoting neuronal outgrowth by utilizing gypican 2 that binds to receptor protein tyrosine phosphatase sigma. These methods involve contacting neurons with agents that induce neuronal outgrowth by clustering RPTPδ or inhibiting the binding of chondroitin sulfate proteoglycan to RPTPδ. The agents can include heparan sulfate proteoglycan, heparan sulfate, and heparin oligosaccharides, among others. Additionally, he has developed methods for treating neuronal injury by administering agents that bind RPTPδ to the site of injury, thereby promoting recovery.
Another notable patent involves a cytoplasmic protein known as PDZ-RGS3, which binds B ephrins through a PDZ domain and regulates heterotrimeric G protein signaling. This invention reveals a pathway linking reverse signaling to cellular guidance and provides methods for modulating cell migration in response to chemokines and GPCR interactions. These advancements have potential applications in treating diseases, including cancer and autoimmune responses.
Career Highlights
Throughout his career, Flanagan has worked with esteemed institutions such as Harvard College and Children's Medical Center Corporation. His research has significantly advanced the understanding of neuronal signaling and growth, contributing to the development of therapeutic strategies for various neurological conditions.
Collaborations
Flanagan has collaborated with notable colleagues, including Philip Leder and Hwai-Jong Cheng, further enhancing the impact of his research through shared expertise and innovative ideas.
Conclusion
John G. Flanagan's work in neuronal growth and signaling exemplifies the importance of innovation in addressing complex medical challenges. His patents and research contributions continue to pave the way for advancements in neuroscience and therapeutic interventions.