The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 1998
Filed:
Dec. 14, 1993
Applicant:
Inventors:
Avner Yayon, Rehovot, IL;
David M Ornitz, Brookline, MA (US);
Michael Klagsbrun, Newton, MA (US);
Philip Leder, Chestnut Hill, MA (US);
John G Flanagan, Newton, MA (US);
Assignees:
The Children's Medical Center Corporation, Boston, MA (US);
President and Fellows of Harvard College, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q / ; C12N / ;
U.S. Cl.
CPC ...
435721 ; 435697 ; 435325 ; 530350 ; 530402 ;
Abstract
A homogeneous population of cells having on average (1) a number of cell surface low-affinity heparin-binding growth factor (HBGF) sites per cell less than 20% of the number of such binding sites found on wild-type CHO-K1 cells (ATCC Accession No. CCL61), and at least three times the number of cell surface high-affinity HBGF receptors per cell found on such CHO-K1 cells; and an assay system utilizing such cells.