The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Feb. 17, 2012
John G. Flanagan, Weston, MA (US);
Yingjie Shen, Brighton, MA (US);
Edith Yvonne Jones, Oxford, GB;
Alexandru Radu Aricescu, Oxford, GB;
Charlotte Hannah Coles, Bonn, DE;
John G. Flanagan, Weston, MA (US);
Yingjie Shen, Brighton, MA (US);
Edith Yvonne Jones, Oxford, GB;
Alexandru Radu Aricescu, Oxford, GB;
Charlotte Hannah Coles, Bonn, DE;
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD, Oxford, GB;
Abstract
Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.