Company Filing History:
Years Active: 2017-2021
Title: Innovations by Inventor Jing Wen
Introduction
Jing Wen is an accomplished inventor based in Culver City, CA (US). He holds a total of 5 patents that showcase his contributions to the field of protein delivery systems. His innovative work focuses on developing advanced nanocapsules that enhance the efficacy of protein therapies.
Latest Patents
One of his latest patents is titled "Protein nanocapsules with detachable zwitterionic coating for protein delivery." This invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g., at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g., tumor cells). Another significant patent is "Stealth nanocapsules for protein delivery." This invention relates to methods and materials for extending the circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N'-methylenebisacrylamide (BIS) crosslinker.
Career Highlights
Jing Wen has worked with notable institutions such as the University of California and Vivibaba, Inc. His experience in these organizations has contributed significantly to his research and development efforts in the field of nanotechnology and protein delivery systems.
Collaborations
He has collaborated with esteemed colleagues, including Yunfeng Lu and Irvin S. Y. Chen. These partnerships have fostered a collaborative environment that enhances innovation and research outcomes.
Conclusion
Jing Wen's innovative work in protein delivery systems through his patented technologies demonstrates his significant contributions to the field. His research continues to pave the way for advancements in therapeutic applications.
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