The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Sep. 04, 2012
Yunfeng LU, Culver City, CA (US);
Tatiana Segura, Los Angeles, CA (US);
Suwei Zhu, Los Angeles, CA (US);
Jing Wen, Culver City, CA (US);
Yunfeng Lu, Culver City, CA (US);
Tatiana Segura, Los Angeles, CA (US);
Suwei Zhu, Los Angeles, CA (US);
Jing Wen, Culver City, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein. In illustrative embodiments, polymer components of the shell are interconnected by peptide-containing crosslinker moieties, linkages which maintain the integrity of the polymer shell under certain environmental conditions, but can also be cleaved when combined with a selected protease.