University of California

Vivibaba, Inc

Jing Wen

Yunfeng Lu

Irvin S Y Chen

Ming Yan

Yang Liu

Min Liang

Masakazu Kamata

Tatiana Segura

Jie Li

Jie Ren

Gan Liu

Suwei Zhu

Irvin Sy Chen

Irvin SY Chen

The invention relates to protein nanocapsules that exhibit material properties that change in different in vivo environments. A zwitterion moiety on the surface of the nanocapsule can protect the protein from opsonization in a first environment, yet uncouples from the protein nanocapsule in a second environment (e.g. at a pH of less than 6.5). In embodiments of the invention, the uncoupled protein nanocarrier is then internalized by mammalian cells (e.g. tumor cells).

Protein nanocapsules with detachable zwitterionic coating for protein delivery

The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N'-methylenebisacrylamide (BIS) crosslinker.

Stealth nanocapsules for protein delivery

Novel siRNA and shRNA nanocapsules and delivery methods are disclosed herein. These siRNA and shRNA nanocapsules and delivery methods are highly robust and effective. This invention provides a platform for RNAi delivery with low toxicity and long intracellular half-life for practical therapeutic applications.

RNAi molecule delivery platform based on single-siRNA and shRNA nanocapsules

The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein. In illustrative embodiments, polymer components of the shell are interconnected by peptide-containing crosslinker moieties, linkages which maintain the integrity of the polymer shell under certain environmental conditions, but can also be cleaved when combined with a selected protease.

Enzyme responsive nanocapsules for protein delivery

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Culver City, CA, United States of America

Jing Wen