The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Nov. 20, 2015
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Yunfeng Lu, Culver City, CA (US);
Yang Liu, Los Angeles, CA (US);
Jing Wen, Culver City, CA (US);
Gan Liu, Los Angeles, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 47/34 (2017.01); A61K 48/00 (2006.01); C09D 4/00 (2006.01); C08F 230/02 (2006.01); C08L 33/04 (2006.01); A61K 47/69 (2017.01); A61K 47/58 (2017.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 9/513 (2013.01); A61K 9/51 (2013.01); A61K 47/34 (2013.01); A61K 47/58 (2017.08); A61K 47/6925 (2017.08); A61K 48/00 (2013.01); C08F 230/02 (2013.01); C08L 33/04 (2013.01); C09D 4/00 (2013.01); B82Y 5/00 (2013.01);
Abstract
The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N'-methylenebisacrylamide (BIS) crosslinker.