Jing Wang

Title: Innovations and Contributions of Inventor Jing Wang

Introduction

Jing Wang is an accomplished inventor based in Nanjing, China, known for his significant contributions to the fields of genetic engineering and polypeptide preparation. With a total of two patents to his name, Wang's work showcases his dedication to advancing scientific knowledge and practical applications in biotechnology.

Latest Patents

Wang's latest innovations include two notable patents:

1. **Fusion protein and its preparation method for intermediate polypeptide of Semaglutide** - This invention discloses a fusion protein and its preparation method for the intermediate polypeptide of Semaglutide. It belongs to the technical field of genetic engineering and polypeptide preparation. The fusion protein comprises a fusion peptide, a protease cleavage site, and a target main molecular sequence. By optimizing the fusion peptide sequence and modifying the isoelectric point and hydrophilicity of the protein, the highest expression of the fusion protein is effectively increased to 13.1 g/L. This advancement not only improves the properties of the fusion protein but also facilitates subsequent extraction, enzyme digestion, and purification processes. Moreover, the yield of the intermediate polypeptide after enzyme digestion is reported to be 3.62 g/L, which significantly reduces the production cost of Semaglutide intermediate polypeptide Arg34GLP-1(9-37), making it suitable for industrial-scale production.

2. **Method for photocleavage of amide bonds** - This disclosure presents a novel method for photocleavage of amide bonds under mild reaction conditions using light. The method entails reacting 2,4-dinitrofluorobenzene with an amino group of a compound represented by a specific structural formula, followed by a cleavage reaction of the amide bond under light irradiation. The innovative approach can involve various side chain groups, demonstrating versatility in application.

Career Highlights

Jing Wang has gained valuable experience through his associations with prominent institutions. He has worked at Nanjing Tech University, where he honed his research skills and contributed to academic advancement. Wang also collaborated with Nanjing Hanxin Pharmaceutical Technology Co., Ltd., focusing on practical applications of his research findings in the pharmaceutical industry.

Collaborations

Throughout his career, Wang has had the opportunity to work alongside respected professionals, including his coworkers Xiaoqiang Chen and Tingwen Wei. These collaborations have enriched his research experience and allowed for the pooling of expertise in the field of biotechnology.

Conclusion

Jing Wang's innovative patents and career reflect his significant impact on genetic engineering and biotechnology. His work not only advances scientific understanding but also paves the way for practical applications that can benefit industrial production and improve healthcare outcomes. With continued dedication, Wang is poised to make further contributions to the field of biotechnology.