Jin-Yuan Shih

Title: Innovations of Jin-Yuan Shih in Lung Cancer Therapy

Introduction

Jin-Yuan Shih is a prominent inventor based in Taipei, Taiwan. He has made significant contributions to the field of cancer research, particularly in the area of lung cancer therapy. With a total of 2 patents, his work focuses on improving the efficacy assessment of cancer treatments.

Latest Patents

One of his latest patents is a "Rapid efficacy assessment method for lung cancer therapy." This invention discloses a method for rapid assessment of lung cancer therapy efficacy in just a few days, as opposed to the weeks required by conventional imaging methods. This innovative approach can also detect cancer relapse and enhance the current TNM cancer staging method for more accurate prognosis. The rapid assessment is based on detecting circulating cancer cells in body fluid, achieving a high positive detection rate through qPCR amplification of multiple marker genes identified via in silico search of DNA sequence databases. Additionally, this invention includes a scoring method to calculate cancer cell load based on qPCR results, correlating the amount of circulating cancer cells in lung cancer patients with predicted treatment outcomes.

Another significant patent is related to "Collapsin response mediator protein-1." This invention is based on the discovery of an association between Collapsin Response Mediator Protein-1 (CRMP-1) and tumor metastasis. The level of CRMP-1 protein or mRNA can serve as an indicator of cellular invasiveness and the ability of a test compound to alter this invasiveness. Furthermore, the level of CRMP-1 protein can be modified to reduce invasiveness.

Career Highlights

Jin-Yuan Shih has worked with esteemed institutions such as the National Health Research Institutes and National Taiwan University. His career reflects a commitment to advancing cancer research and improving patient outcomes through innovative methodologies.

Collaborations

Throughout his career, Jin-Yuan Shih has collaborated with notable colleagues, including Pan-Chyr Yang and Konan Peck. These collaborations have further enriched his research and contributed to the development of his patents.

Conclusion

Jin-Yuan Shih's innovative work in lung cancer therapy exemplifies the potential of scientific research to transform patient care. His patents not only enhance the understanding of cancer treatment efficacy but also pave the way for more accurate prognostic methods.