National Health Research Institutes

National Taiwan University

Academia Sinica

Jin-Yuan Shih

Pan-Chyr Yang

Konan Peck

Cheng-Wen Wu

Tse-Ming Hong

Jeremy J W Chen

Shuenn-Chen Yang

Yuh-Pyng Sher

The present invention discloses a method for rapid assessment of lung cancer therapy efficacy in a few days instead of weeks by conventional imaging methods. This method can also be used to detect relapse of the cancer and to improve the current TNM cancer staging method for more accurate prognosis. The rapid assessment of therapy efficacy is based on detecting circulating cancer cells in body fluid with high positive detection rate. The high positive detection rate is achieved by using qPCR amplification of multiple marker genes identified by in silico search of DNA sequence database. This invention also discloses a scoring method to calculate the cancer cell load based on qPCR results to correlate the amount of circulating cancer cells in lung cancer patients and predict the treatment outcomes.

Rapid efficacy assessment method for lung cancer therapy

This invention is based on the discovery of an association of Collapsin Response Mediator Protein-1 (CRMP-1) with tumor metastasis. The level of CRMP-1 protein or mRNA can be used as an indicator of cellular invasiveness and of a test compound's ability to alter cellular invasiveness. The level of CRMP-1 protein can also be altered, e.g., to reduce invasiveness.

Collapsin response mediator protein-1

Growing community of inventors

Taipei, Taiwan

Jin-Yuan Shih