Jin-an Jiao

Title: Innovator Jin-an Jiao: Pioneering Advances in Anti-Coagulant Antibodies

Introduction

Jin-an Jiao, an accomplished inventor based in Fort Lauderdale, FL, has made significant contributions to the biomedical field, particularly in the development of anti-tissue factor antibodies. Holding 14 patents to his name, Jiao's work has the potential to transform therapeutic approaches to blood coagulation disorders.

Latest Patents

Jiao's latest patents focus on innovative anti-tissue factor antibodies and methods of their use. His invention includes antibodies that demonstrate superior anti-coagulant activity by binding native human tissue factor (TF) with high affinity and specificity. These antibodies are capable of effectively inhibiting blood coagulation in vivo. Remarkably, they have the ability to bind native human TF, either independently or within a TF:FVIIa complex. This binding action prevents factor X or FIX from binding to TF or the complex, ultimately reducing blood coagulation. A characteristic feature of the antibodies is their specificity for a conformational epitope predominantly found in native human TF, providing an unexpectedly robust binding site. Furthermore, the invention includes humanized antibodies and fragments that specifically attach to the TF.

Additionally, Jiao has developed methodologies for treating thrombosis in mammals, especially humans. One preferred method involves administering a therapeutically effective amount of a humanized antibody, chimeric antibody, or its fragment, specifically designed to bind to human tissue factor (TF). This invention opens new avenues for preventing or treating thrombosis and includes additional methods and kits for practical application.

Career Highlights

Throughout his career, Jin-an Jiao has held pivotal roles in notable companies within the biotechnology sector, including Sunol Molecular Corporation and Genentech, Inc. His tenure in these companies has honed his skills and allowed him to contribute significantly to breakthrough research and development in therapeutics.

Collaborations

Jiao has collaborated with esteemed colleagues, including Hing C Wong and Esperanza Liliana Nieves. These partnerships have fostered innovation and have been instrumental in advancing their shared goals in biomedical research.

Conclusion

Jin-an Jiao stands as a prominent figure in the realm of anti-coagulant therapy innovation. With a robust history of patents and research endeavors, he exemplifies the spirit of inventiveness that drives medical progress. His work continues to pave the way for new treatments and improved patient outcomes in thrombotic disorders, marking a significant impact on both the scientific and medical communities.