The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Jul. 06, 2001
Hing C. Wong, Fort Lauderdale, FL (US);
Peter R. Rhode, Miami, FL (US);
Jon A. Weidanz, Miami, FL (US);
Susan Grammer, Coral Gables, FL (US);
Ana C. Edwards, Miami, FL (US);
Pierre-andre Chavaillaz, Cooper City, FL (US);
Jin-an Jiao, Fort Lauderdale, FL (US);
Hing C. Wong, Fort Lauderdale, FL (US);
Peter R. Rhode, Miami, FL (US);
Jon A. Weidanz, Miami, FL (US);
Susan Grammer, Coral Gables, FL (US);
Ana C. Edwards, Miami, FL (US);
Pierre-Andre Chavaillaz, Cooper City, FL (US);
Jin-An Jiao, Fort Lauderdale, FL (US);
Altor Bioscience Corporation, Miramar, FL (US);
Abstract
The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.