The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Mar. 13, 2009
Jin-an Jiao, Fort Lauderdale, FL (US);
Hing C. Wong, Fort Lauderdale, FL (US);
Esperanza Liliana Nieves, Newark, DE (US);
Luis A. Mosquera, Miami, FL (US);
Jin-an Jiao, Fort Lauderdale, FL (US);
Hing C. Wong, Fort Lauderdale, FL (US);
Esperanza Liliana Nieves, Newark, DE (US);
Luis A. Mosquera, Miami, FL (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.