Luis A Mosquera

Title: Innovations by Inventor Luis A. Mosquera in the Field of Anti-Coagulant Therapies

Introduction

Luis A. Mosquera is a prominent inventor based in Miami, FL, who has made significant contributions to the field of biotechnology, particularly in the development of anti-coagulant therapies. With a portfolio that includes two patents, Mosquera is recognized for his innovative approaches to treating thrombosis effectively.

Latest Patents

Mosquera's latest patents focus on "Anti-tissue factor antibodies and methods of use thereof" and "Use of anti-tissue factor antibodies for treating thromboses." The first invention describes antibodies that exhibit superior anti-coagulant activity by binding to native human tissue factor (TF) with high affinity and specificity. These antibodies effectively inhibit blood coagulation in vivo by preventing factor X or FIX from binding to TF or TF:FVIIa complexes. The preferred antibodies specifically target a conformational epitope that offers a surprisingly strong binding site. Additionally, humanized antibodies and fragments that bind to TF are also provided in this invention.

The second patent outlines methods for preventing or treating thrombosis in mammals, particularly humans. This includes administering a therapeutically effective dose of at least one humanized or chimeric antibody that binds specifically to human TF. The invention presents additional methods and kits for application in clinical settings.

Career Highlights

Luis A. Mosquera is affiliated with Genentech, Inc., a company renowned for its cutting-edge research and development in biotechnology and pharmaceuticals. His work here has been pivotal in advancing therapeutic options for patients suffering from coagulation disorders. His dedication to research and development has set a standard in the industry, contributing to potentially life-saving treatments.

Collaborations

Throughout his career, Mosquera has collaborated with notable colleagues such as Jin-an Jiao and Hing C. Wong. These collaborations have facilitated the exchange of ideas and technologies, propelling their mutual interests in the biotech field forward and enhancing the effectiveness of their innovations.

Conclusion

Luis A. Mosquera embodies the spirit of innovation in the medical field through his groundbreaking patents that target coagulation-related disorders. His work not only addresses critical health issues but also paves the way for future advancements in antibody-based therapies. The impact of his contributions at Genentech, Inc. continues to influence the development of effective treatments for thrombosis, ultimately benefiting patients worldwide.