Jia-Wen Han

Title: Innovations and Contributions of Inventor Jia-Wen Han

Introduction

Jia-Wen Han is a notable inventor based in Newton, MA, who has made significant contributions to the field of biomedical research. With a total of two patents to his name, his work focuses on innovative methods for treating diseases, particularly cancer.

Latest Patents

One of Jia-Wen Han's latest patents involves peptidomimetic macrocycles. These macrocycles comprise a helix, such as an alpha helix, and are designed for the treatment of diseases like cancer. The invention includes an α,α-disubstituted amino acid and may feature a crosslinker linking the α-positions of at least two amino acids. Additionally, it targets components of the Wnt signaling pathway, specifically the Tcf4-/β-catenin complex. Another significant patent pertains to the bbc3 gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression. This invention outlines methods for identifying compounds that modulate apoptosis, either directly or indirectly, by measuring changes in the expression of the bbc3 gene or a reporter gene.

Career Highlights

Throughout his career, Jia-Wen Han has worked with prominent companies in the biotechnology sector, including Aileron Therapeutics, Inc. and Immunogen, Inc. His experience in these organizations has contributed to his expertise in developing innovative solutions for complex medical challenges.

Collaborations

Jia-Wen Han has collaborated with notable colleagues such as Huw M. Nash and Rosana Kapeller-Libermann. These partnerships have likely enhanced his research and development efforts, leading to impactful innovations in his field.

Conclusion

Jia-Wen Han's contributions to biomedical research through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in the treatment of diseases, particularly cancer.