The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2019
Filed:
Nov. 11, 2016
Aileron Therapeutics, Inc., Cambridge, MA (US);
Huw M. Nash, Concord, MA (US);
Rosana Kapeller-Libermann, Chestnut Hill, MA (US);
Jia-Wen Han, Newton, MA (US);
Tomi K. Sawyer, Southborough, MA (US);
Justin Noehre, Cambridge, MA (US);
Noriyuki Kawahata, West Roxbury, MA (US);
AILERON THERAPEUTICS, INC., Cambridge, MA (US);
Abstract
Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an α,α-disubstituted amino acid, or may comprise a crosslinker linking the α-positions of at least two amino acids or at least one of said two amino acids may be an α,α-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.