Immunogen, Inc.

Aileron Therapeutics, Inc.

Jia-Wen Han

Rosana Kapeller-Libermann

Tomi K Sawyer

Huw M Nash

Thomas D Chittenden

Noriyuki Kawahata

Justin Noehre

Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an &#x3b1;,&#x3b1;-disubstituted amino acid, or may comprise a crosslinker linking the &#x3b1;-positions of at least two amino acids or at least one of said two amino acids may be an &#x3b1;,&#x3b1;-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.

Peptidomimetic macrocycles

The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptotic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. The present invention is further directed to a method for modulating apoptosis in a cell, a method for modulating bbc3 gene expression in a cell, a process for making a modulator of apoptosis, and a process for making a modulator of bbc3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.

bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter

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Newton, MA, United States of America

Jia-Wen Han