Location History:
- Taoyuan County, TW (2015)
- Hsinchu, TW (2015)
- New Taipei, TW (2015)
- Taipei, TW (2009 - 2018)
- Taoyuan, TW (2022)
Company Filing History:
Years Active: 2009-2022
Title: Innovations of Jenn-Tzong Chen
Introduction
Jenn-Tzong Chen is a prominent inventor based in Taipei, Taiwan. He has made significant contributions to the field of nuclear energy and radiochemistry, holding a total of 13 patents. His work focuses on the purification and synthesis of radioisotopes, which are crucial for medical imaging and treatment.
Latest Patents
One of his latest patents is a method of high-pressure purification of [F-18]FEONM. This method provides a way to purify [F-18]FEONM under high pressure, integrating the synthesis processes of [F-18]FEONM. The process utilizes a non-toxic radio-high performance liquid chromatography (radio-HPLC) to purify the crude product. The method combines a conventional [F-18]FDG synthesizer with a novel radio-HPLC system in a heat chamber. After radiofluorinating the precursor, the reaction product is purified using an alumina solid-phase column to obtain the crude product while removing fluorine-18. A diphenyl semipreparative HPLC column is then used for final purification, employing a non-toxic solvent for mobile-phase elution to eliminate unreacted precursors and phase-transfer solvents. The radiofluorination achieves a reaction yield of about 50 percent, with an uncorrected radiochemical yield of 10^-20%. Both radio-HPLC and radio-thin layer chromatography (radio-TLC) demonstrate a radiochemical purity exceeding 95%. Another significant patent involves the fabrication of the [F-18]FEONM precursor, where 2-bromoethanol is added to connect an atom of oxygen at the N terminal of the precursor, enhancing fat solubility and improving brain imaging capabilities.
Career Highlights
Jenn-Tzong Chen has worked with the Institute of Nuclear Energy Research, which is part of the Atomic Energy Council under the Executive Yuan of the Republic of China. His expertise in radiochemistry has positioned him as a key figure in the development of innovative methods for synthesizing and purifying radioisotopes.
Collaborations
He has collaborated with notable colleagues, including Wuu-Jyh Lin and Ting-Shien Duh, who have contributed to his research endeavors.
Conclusion
Jenn-Tzong Chen's innovative work in the field of radiochemistry and nuclear energy
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