Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Atomic Energy Council-institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council

Tsinghua University

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

Atomic Energy Council

Jenn-Tzong Chen

Wuu-Jyh Lin

Ting-Shien Duh

Li-Yuan Huang

Shiou-Shiow Farn

Mao-Hsung Chang

Chyng-Yann Shiue

Ying-Ming Tsai

Chien-Hsin Lu

Yean-Hung Tu

Wen-Chin Su

Sun-Rong Huang

Chung-Shan Yu

Ho-Lien Huang

Ching-Shiuann Yang

Dow-Che Chen

Kuo-Yuan Chu

Cheng-Fang Hsu

Show-Wen Liu

Tsai-Yueh Luo

Shu-Hung Lin

Hsin-Ell Wang

Hao-Wen Kao

Sheng-Po Huang

Jainn-Hsin Lu

Ping-Yen Huang

Chun-Nan Yeh

Wei-Yuan Lee

Kang-Wei Chang

Ying-Cheng Huang

Kun-Ju Lin

Shu-Fan Tien

Chuan-Lin Chen

Wen-Yi Chang

Jia-Rong Chen

Sun-Rong Hwang

Yen-Hung Tu

Ying-Chieh Wang

Ying-Ming c/o Atomic En Council-Inst Of Nucl Energy Tsai

Ting-Shien c/o Atomic Energy Council Duh

Dow-Chi Chen

A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10&#x2dc;20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.

Method of high-pressure purification of [f-18]FEONM

A [F-18]FEONM precursor is synthesized. 2-bromoethanol is added to further connect an atom of oxygen at an N terminal of the precursor. Four atoms of carbon can be further connected. Thus, better fat-solubility is obtained along with the increase in carbon. Positioning in brain imaging becomes better.

Method of fabricating [F-18]FEONM precursor

A PET imaging agent is made, by at first, washing out fluoride ions (F-18) adhered on an ion exchange resin to a reaction vessel with potassium carbonate/Kryptofix 2.2.2 in acetonitrile-water. After processing the first azeotropic distillation with helium while water is removed, the temperature is cooled down. Then, acetonitrile is added to the reaction vessel to be heated up. After processing the second azeotropic distillation with helium while water is removed, the temperature is cooled down and excess water is extracted. A precursor is then added to the reaction vessel to be heated up for processing a fluorination reaction. The reaction mixture obtained after the fluorination reaction is cooled down to be flown through a solid-phase extraction column with waste drained into a waste tank. Then, ethanol is used to wash out a product, i.e. [F-18]FEONM, adsorbed by the column, to be collected in a collection vial.

Method of fabricating [F-18]FEONM

A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.

Compound of radiocontrast agent for tau protein

The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.

Method for F-18 FLT synthesis

The present invention provides a method of preparing [I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/&#x3bc;mol and radiochemical purity of 95%. The present invention further provides a method of applying [I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.

[object Object]

AF-labeled monomeric galactose derivative is provided as a tomography probe. The derivative is a positron emission tomography (PET) probe. The derivative has high affinity and good stability in animal's body. The derivative can be an alternative glucose metabolism imaging agent used in clinic examination and quantification.

18F-labeled monomeric galactose derivative used as tomography probe

A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [I]-IaraU, which is distinguishable from [F]-FLT markingF on a glycosyl group to obtain a novel tumor radiation probe. The marking procedures include mixing the marker precursor with Na [I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments, while reducing production cost.

The present invention provides a method for fabricating an indium(In)-111 radioactive isotope. A target of cadmium(Cd)-112 is processed through steps of dissolving with heat, absorbing, washing, desorbing and drying for obtaining the In-111 radioactive isotope. Thus, chemical separation is coordinated with the target for fabricating the In-111 radioactive isotope with high efficiency and low cost for production procedure.

Method of fabricating indium-111 radioactive isotope

Disclosed is a device for separating radioisotope thallium-201. The device includes an evaporation unit for a solution vial, a first glass vial connected to a first valve and a second valve, an ion exchange column connected to a third valve, a second glass vial connected to a fourth valve and a fifth valve, a collection vial for receiving solution from the fifth valve, a product vial with a membrane filter and a vacuum unit connected to the first valve, the fourth valve and a sixth valve. This device can separate out high-concentration thallium-201 solution from which radioisotope thallium-201 can be obtained.

Device for separating out radioisotope thallium-201

A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.

Circulated cooled target

A radioisotope TI-201 is produced. The process includes electroplating, irradiating, dissolving, precipitating, ion exchanging, decaying and filtering. The TI-201 obtained is a liquid having a high purity.

Radioisotope TI-201 production process

A device to rapidly obtain a solution of Pb(lead)-201 from a solution of a solid target material of Tl(thallium)-203. The solution of Pb-201 is then processed through a degeneration and an ion exchange to obtain in Tl-201 radioisotope.

Separation device of radioisotope Tl-201

Growing community of inventors

Taipei, Taiwan

Jenn-Tzong Chen