The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Dec. 10, 2012
Atomic Energy Council-institute of Nuclear Research, Taoyuan County, TW;
Jenn-Tzong Chen, Taipei, TW;
Ho-Lien Huang, Taoyuan County, TW;
Jia-Rong Chen, Miaoli County, TW;
Chung-Shan Yu, Hsinchu, TW;
Wen-Chin Su, Changhua County, TW;
Ching-Shiuann Yang, Taoyuan County, TW;
Wuu-Jyh Lin, Taoyuan County, TW;
Institute of Nuclear Energy Research, Atomic Energy Council, Lungtan, Taoyuan, TW;
Abstract
A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [I]-IaraU, which is distinguishable from [F]-FLT markingF on a glycosyl group to obtain a novel tumor radiation probe. The marking procedures include mixing the marker precursor with Na [I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments, while reducing production cost.