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Title: Innovations of Chung-Shan Yu in Radiochemistry
Introduction
Chung-Shan Yu is a notable inventor based in Hsinchu, Taiwan. He has made significant contributions to the field of radiochemistry, particularly in the development of novel methods and compounds for medical applications. With a total of 3 patents, his work has implications for cancer diagnosis and treatment.
Latest Patents
One of his latest patents involves a method for preparing [I]Iodooctyl fenbufen amide. This method achieves a radiochemical yield of 15%, a specific activity of 37 GBq/μmol, and a radiochemical purity of 95%. This invention provides a method for applying [I]Iodooctyl fenbufen amide as a tracer in single photon emission computed tomography (SPECT) to estimate the distribution of cyclooxygenase. The binding characteristics of the iodine isotope-labeled compounds allow for the estimation of tumor development and metastasis, correlating inflammation with tumor lesions.
Another significant patent is a tumor radiation probe of iodine-123 marker thymidine (FLT) analogue, [I]-IaraU. This probe is synthesized using commercially available uridine as the raw material. The radioactive iodine-123 is marked on an alkaline group of uridine, resulting in a novel tumor radiation probe that is distinguishable from [F]-FLT. The marking procedures enhance the radiochemical purity to over 98% and the yield from 8% to 40%, making it suitable for biological experiments while reducing production costs.
Career Highlights
Chung-Shan Yu has worked with prestigious institutions such as Tsinghua University and the Institute of Nuclear Energy Research, Atomic Energy Council. His research has focused on advancing the field of radiochemistry and its applications in medical diagnostics.
Collaborations
He has collaborated with notable colleagues, including Ho-Lien Huang and Ching-Shiuann Yang, contributing to the advancement of innovative solutions in his field.
Conclusion
Chung-Shan Yu's contributions to radiochemistry through his patents and collaborations highlight his role as an influential inventor in the medical field. His work continues to pave the way for advancements in cancer diagnostics and treatment.