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Years Active: 2021-2024
Title: Jason Daniel Buenrostro: Innovator in Genomic Technologies
Introduction
Jason Daniel Buenrostro is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of genomics, particularly in the analysis of cellular and mitochondrial DNA. With a total of 3 patents, his work has advanced our understanding of cell lineage and genetic barcoding.
Latest Patents
Buenrostro's latest patents include groundbreaking methods for lineage tracing using mitochondrial genome mutations and single-cell genomics. These embodiments provide innovative methods to use somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts. They also serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Furthermore, his work demonstrates that mitochondrial mutations can be detected using contemporary single-cell transcriptomic and epigenomic technologies, allowing for the simultaneous capture of gene expression profiles and chromatin accessibility.
Another notable patent involves methods and compositions for analyzing nucleic acids in individual cells. This includes generating fragmented cellular genomic DNA and cDNA copies of cellular RNA molecules within individual cells. The methods also involve barcoding the fragmented genomic DNA and cDNA, isolating them, and characterizing features of the individual cells based on sequencing.
Career Highlights
Buenrostro has worked at prestigious institutions such as the Massachusetts Institute of Technology and Harvard College. His experience in these leading research environments has significantly influenced his innovative work in genomics.
Collaborations
He has collaborated with notable scientists, including Aviv Regev and Fei Chen, further enhancing the impact of his research in the scientific community.
Conclusion
Jason Daniel Buenrostro is a key figure in the field of genomic technologies, with his patents paving the way for advancements in understanding cellular dynamics and genetic analysis. His contributions continue to influence research and innovation in genomics.