Location History:
- Palos Verdes Estates, CA (US) (1993)
- Los Angelos, CA (US) (2017)
- Los Angeles, CA (US) (1991 - 2023)
Company Filing History:
16 out of 18 
4 out of 142 
2 out of 7 
Years Active: 1991-2025
Title: Innovations by Jar-How Lee in HLA Typing and Transfusion Reaction Diagnostics
Introduction
Jar-How Lee, based in Los Angeles, CA, is an accomplished inventor credited with 22 patents. His work focuses on developing innovative methods and tools that enhance the capabilities of medical diagnostics, particularly in the area of human leukocyte antigen (HLA) typing.
Latest Patents
Among his latest inventions is a method for single reaction multiplex PCR primer design aimed at amplifying multiple HLA class I and II genes. This cutting-edge technique provides next-generation sequencing (NGS)-based high-resolution HLA typing as a routine clinical test. By simplifying the protocol and significantly reducing the number of amplification reactions—by nearly ten-fold—this invention ensures a substantially equimolar ratio of individual HLA gene amplification products. The elimination of the amplicon pooling step not only reduces reagent costs but also the required sample DNA quantity.
Another notable patent involves modified Fc gamma receptor type III (FcγRIII, HNA-1) polypeptides, where Lee has engineered these polypeptides for the detection of antibodies specific to human neutrophil antigens (HNA). This invention further includes methods for diagnosing and determining susceptibility to developing Transfusion Reaction Acute Lung Injury (TRALI).
Career Highlights
Lee has significantly contributed to the field of immunology and molecular biology through his roles in leading companies such as One Lambda, Inc. and Xoma Corporation. His innovative approaches to HLA typing and diagnostics have established him as a thought leader in his industry.
Collaborations
Throughout his career, Jar-How Lee has collaborated with esteemed colleagues, including Rui Pei and Jiunu S Lai. Their combined expertise has undoubtedly propelled advancements in the field of medical diagnostics, fostering a culture of innovation.
Conclusion
In summary, Jar-How Lee stands out as an influential inventor whose work in HLA typing and transfusion reactions is creating significant impacts in clinical practice. With his impressive portfolio of 22 patents, he continues to drive forward the boundaries of innovation in the medical field.