Location History:
- Bloomington, IN (US) (1992)
- Indianapolis, IN (US) (1992 - 1994)
Company Filing History:
3 out of 4,447 
1 out of 29 Years Active: 1992-1994
Title: The Innovative Contributions of James P McDonough in Protein Engineering
Introduction
James P McDonough, an accomplished inventor based in Indianapolis, IN, has been instrumental in advancing the field of protein engineering. With a total of three patents to his name, he has made significant contributions, particularly in the development of processes that enhance the production of bioactive proteins such as insulin.
Latest Patents
Among his notable patents, McDonough has focused on the enzymatic removal of a protein amino-terminal sequence. This invention revolves around the creation of new compounds and processes that allow for the controlled conversion of these compounds into proteins that serve as precursors for human insulin or modified human insulin. These proteins exhibit an amino acid sequence that avoids specific cathepsin C dipeptide removal stop points. The compounds generated by this process are characterized by the formula Met-Y-Protein, where Y can be either Tyr or Arg. This innovation holds potential for enhancing insulin synthesis and improving diabetes management.
Career Highlights
James P McDonough has had a fruitful career working with prominent companies in the pharmaceutical and biotechnology sectors. Notable organizations he has been associated with include Eli Lilly and Company and Hybritech Incorporated. His work in these companies has allowed him to leverage his expertise in protein engineering, driving forward essential research and innovations.
Collaborations
Throughout his career, McDonough has collaborated with talented coworkers such as Thomas C Furman and Gerald W Becker. These collaborations have fostered a rich exchange of ideas and expertise, contributing to the successful development of his innovative patents.
Conclusion
James P McDonough's contributions to the field of protein engineering, particularly in the context of human insulin production, underscore his importance as an inventor. His patents not only showcase his innovative spirit but also demonstrate the potential for enhancing therapeutic solutions in medicine. As the demand for effective diabetes treatment continues to grow, McDonough's work remains relevant and impactful.