The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 1992
Filed:
Jun. 09, 1989
Applicant:
Inventors:
James P McDonough, Bloomington, IN (US);
Thomas C Furman, Indianapolis, IN (US);
Richard M Bartholomew, San Diego, CA (US);
Rodney A Jue, San Diego, CA (US);
Assignees:
Eli Lilly and Company, Indianapolis, IN (US);
Hybritech Incorporated, San Diego, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ;
U.S. Cl.
CPC ...
435 681 ; 435 691 ; 435 695 ; 435272 ; 43524027 ; 530402 ; 5303881 ; 5303873 ; 53038815 ;
Abstract
Novel methods for reducing the heterogeneity of secreted monoclonal antibodies are disclosed. The first method comprises incubating the heterogeneous antibodies at low pH for a length of time sufficient to convert the heterogeneous forms of antibodies into substantially homogeneous forms. Another method produces the same result using ascites fluid, while yet another method produces the same result using carboxypeptidase. The homogeneous antibodies can then be purified in high yield.