Baltimore, MD, United States of America

James J Frost


Average Co-Inventor Count = 5.0

ph-index = 1

Forward Citations = 34(Granted Patents)


Company Filing History:


Years Active: 2006-2013

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2 patents (USPTO):Explore Patents

Title: Innovator James J. Frost: Pioneering Non-Invasive Diagnostic Imaging Technology

Introduction: James J. Frost is an accomplished inventor based in Baltimore, MD, renowned for his contributions to the field of diagnostic imaging. With a total of two patents, his work is primarily focused on leveraging advanced technologies to improve the assessment of mitochondrial dysfunction in patients.

Latest Patents: Frost's latest patents highlight his innovative approaches towards non-invasive diagnostic imaging. The first patent, titled "Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts," describes a method using lipophilic salts that comprise a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. These salts demonstrate an affinity for dysfunctional mitochondria, allowing for improved imaging of cardiovascular diseases and disorders. The invention also details pharmaceutical compositions and methods for employing these lipophilic salts.

The second patent, "Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts," introduces a series of lipophilic phosphonium cations labeled with fluorine for non-invasive assessment. This innovation includes lipophilic ammonium cation analogs of the phosphonium cations and provides methods for imaging and detecting mitochondrial-related pathologies in patients through PET or SPECT imaging techniques.

Career Highlights: James J. Frost has made significant strides in his career, primarily through his association with The Johns Hopkins University. His research has been instrumental in advancing the field of cardiovascular diagnostics, particularly through the use of non-invasive techniques that enhance patient care and outcomes.

Collaborations: Throughout his career, Frost has collaborated with notable colleagues, including Igal Madar and Hayden T. Ravert. These partnerships contribute to a rich environment of innovation and advancement in medical technology, enabling further development of diagnostic methodologies.

Conclusion: James J. Frost stands as a significant figure in the realm of diagnostic imaging, with his inventive technologies paving the way for advancements in identifying and treating mitochondrial dysfunction. His patents exemplify the fusion of chemistry and medicine, showcasing the potential for innovation in improving patient diagnostics and outcomes.

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