The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2013
Filed:
Feb. 06, 2003
Igal Madar, Baltimore, MD (US);
Hayden T. Ravert, Bel Air, MD (US);
Robert Francis Dannals, Sparks, MD (US);
Ursula A. Scheffel, Baltimore, MD (US);
James J. Frost, Baltimore, MD (US);
Igal Madar, Baltimore, MD (US);
Hayden T. Ravert, Bel Air, MD (US);
Robert Francis Dannals, Sparks, MD (US);
Ursula A. Scheffel, Baltimore, MD (US);
James J. Frost, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.