Location History:
- Somerville, MA (US) (2021 - 2023)
- Wakefield, MA (US) (2023)
Company Filing History:
4 out of 8,373 
1 out of 197 
Years Active: 2021-2023
**Title: Inventor Profile: James C. Kaczmarek**
Introduction
James C. Kaczmarek, located in Somerville, Massachusetts, is a notable inventor recognized for his contributions to the field of polymer science. With four patents to his name, Kaczmarek has made significant advancements in the development of branched poly(beta-amino esters), particularly in their applications for therapeutic delivery systems.
Latest Patents
Kaczmarek's latest patents include innovations that leverage poly(beta-amino esters) (PBAE) for therapeutic agent delivery. One such patent, "Poly(beta-amino esters) and uses thereof," describes PBAE as efficient vehicles for delivering nucleic acids, capable of forming stable compositions suitable for nebulization. These compositions demonstrate the potential to deliver therapeutic agents like mRNA directly to lung epithelial cells. Additionally, his patent on "Polymer-lipids and compositions" outlines improved selection and formulation processes for PBAE polymers using a design of experiment approach, which employs statistical methods to optimize experimental conditions and enhance polymer properties.
Career Highlights
Kaczmarek has had a distinguished career, working with prestigious institutions including the Massachusetts Institute of Technology and Politecnico Di Milano. His role in these organizations has allowed him to collaborate on groundbreaking research, furthering the field of polymer applications in medicine.
Collaborations
Throughout his career, Kaczmarek has collaborated with esteemed colleagues such as Daniel Griffith Anderson and Kevin John Kauffman. These partnerships have contributed to the innovative spirit that drives advancements in the functionality of PBAE polymers and their therapeutic applications.
Conclusion
James C. Kaczmarek is a pioneering inventor whose work with poly(beta-amino esters) showcases the intersection of chemistry and medicine. His dedication to developing effective delivery systems for therapeutic agents continues to impact the field, reflecting a commitment to innovation and collaboration that is essential in addressing modern healthcare challenges.