Massachusetts Institute of Technology

Politecnico Di Milano

James C Kaczmarek

Daniel Griffith Anderson

Kevin John Kauffman

Asha Kumari Patel

Davide Moscatelli

Umberto Capasso Palmiero

Luke Hyunsik Rhym

Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

Poly(beta-amino esters) and uses thereof

The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.

Polymer-lipids and compositions

Poly (beta-amino esters) and uses thereof

Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (&#x3b2;-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

Gene delivery carrier

Growing community of inventors

Somerville, MA, United States of America

James C Kaczmarek