Location History:
- Boston, MA (US) (2018)
- Cambridge, MA (US) (2018 - 2021)
- Charlestown, MA (US) (2020 - 2024)
Company Filing History:
Years Active: 2018-2025
Title: The Innovative Mind of James Angstman: Revolutionizing Genetic Repair
Introduction
James Angstman, a prominent inventor based in Cambridge, Massachusetts, has made significant contributions to the field of genetic engineering with a total of nine patents to his name. His innovative work focuses on enhancing the efficiency of gene editing techniques, particularly in the realm of homology-directed repair (HDR), which holds great potential for advancements in genetic therapies.
Latest Patents
Two of James Angstman’s latest patents showcase his groundbreaking approach to improving HDR techniques. The first patent, titled "Methods for Increasing Efficiency of Nuclease-Induced Homology-Directed Repair," describes innovative methods to enhance the absolute and relative rates of HDR compared to non-homologous end joining (NHEJ). This work aims to streamline genetic repairs, opening new avenues for medical treatments.
The second patent, "TAL-Tet1 Fusion Proteins and Methods of Use Thereof," focuses on the development of fusion proteins that combine a DNA-binding domain, such as a TAL effector repeat array, with a catalytic domain capable of hydroxylating methylated cytosines in DNA. This technological advancement could significantly improve the precision of genetic modifications.
Career Highlights
Currently, James Angstman is affiliated with The General Hospital Corporation, where he applies his extensive knowledge in genetics and molecular biology to create transformative healthcare solutions. His work is instrumental in positioning the organization as a leader in innovative health technologies.
Collaborations
Throughout his career, Angstman has collaborated with esteemed colleagues, including J. Keith Joung and Morgan Maeder. Together, they have pushed the boundaries of genetic research, fostering an environment of innovation and discovery.
Conclusion
James Angstman's contributions to genetic engineering through his patented inventions illustrate his commitment to enhancing the efficiency of crucial genetic repair methods. His work not only advances scientific understanding but also paves the way for future breakthroughs in medical treatment and genetic therapies. With an impressive portfolio of patents and valuable collaborations, Angstman continues to be a driving force in the field of innovation.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.