The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2021
Filed:
Oct. 01, 2015
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
J. Keith Joung, Cambridge, MA (US);
Benjamin Kleinstiver, Medford, MA (US);
Jason Michael Gehrke, Santa Barbara, CA (US);
Shengdar Tsai, Memphis, TN (US);
James Angstman, Cambridge, MA (US);
Rebecca Tayler Cottman, Cambridge, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/90 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/10 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C12N 15/63 (2013.01); C07K 2319/00 (2013.01); C07K 2319/09 (2013.01); C07K 2319/095 (2013.01); C07K 2319/80 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract
The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).